Correlation of Histologic Features with in Vivo Imaging of Reticular Pseudodrusen

U Greferath; RH Guymer; KA Vessey; K Brassington; EL Fletcher

Journal article

Correlation of Histologic Features with in Vivo Imaging of Reticular Pseudodrusen

U Greferath, RH Guymer, KA Vessey, K Brassington, EL Fletcher

Ophthalmology | ELSEVIER SCIENCE INC | Published : 2016

DOI: 10.1016/j.ophtha.2016.02.009

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Abstract

Purpose To determine the histologic and cellular correlates in the retina and retinal pigment epithelium (RPE) with the presence of optical coherence tomography-defined reticular pseudodrusen (RPD). Design Observation case using immunocytochemistry of an exenterated eye with immediate fixation after removal. Participants Two patients, one with confirmed RPD and the other with mid-peripheral drusen, underwent multimethod imaging before exenteration and immediate fixation of the posterior eyecup for high-resolution immunocytochemical analysis. Methods Optical coherence tomography (OCT) was compared with high-resolution immunocytochemistry using a range of cellular markers to determine changes ..

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University of Melbourne Researchers

Una Greferath Author

Robyn Guymer Author

Kirstan Vessey Author

Erica Fletcher Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Supported by the National Health and Medical Research Council of Australia, Canberra (grant nos.: APP1027624 and 1061419 [R.H.G., K.A.V., E.L.F.]); and the Macular Diseases Foundation of Australia Sydney (R.H.G., K.A.V., E.L.F.).